Lady GH contains recombinant human growth hormone (rhGH), also known as somatropin. It is a single-chain polypeptide of 191 amino acids with a molecular weight of approximately 22,124 Da. The sequence is identical to endogenous pituitary-derived human growth hormone. Somatropin is produced using recombinant DNA technology in a mammalian cell expression system, ensuring full biological equivalence to the native hormone.
Mechanism of Action
Somatropin binds to the growth hormone receptor (GHR) on target cells, inducing receptor dimerization and activation of the JAK2/STAT5 signalling pathway. Key downstream effects include:
Stimulation of insulin-like growth factor–1 (IGF–1) production in liver and local tissues
Promotion of lipolysis in adipose tissue and inhibition of lipogenesis
Increased protein synthesis and amino acid uptake in muscle
Enhancement of collagen synthesis and extracellular matrix remodelling
Stimulation of chondrocyte proliferation in growth plates (prior to epiphyseal closure)
Age under 18 years (unless under specialist endocrinology care)
Pregnancy or breastfeeding
Warnings
Use only under medical supervision with regular monitoring (IGF-1 levels, glucose, thyroid function, and clinical parameters).
Not a substitute for lifestyle interventions, approved therapies for metabolic disorders, or treatment of underlying conditions.
Increased risk of glucose intolerance, diabetes, or worsening of pre-existing diabetes.
Potential for fluid retention, arthralgia, myalgia, or carpal tunnel syndrome (usually transient). Discontinue immediately and seek medical attention if signs of intracranial hypertension (severe headache, visual changes), pancreatitis, or severe allergic reaction occur.
Dosage & Administration
Subcutaneous injection only.
Standard Dose: 1 IU per day (1 dose = 1 IU)
1 IU ≈ 8 clicks
Quick reference:
2 IU = 16 clicks
3 IU = 24 clicks
4 IU = 32 clicks
5 IU = 40 clicks
Frequency: Daily dosing, with 2-3 days off per week recommended for optimal long-term benefit
Timing: Best taken in the morning on an empty stomach or as directed by your healthcare provider Cycle: 4-6 weeks on, followed by a break as advised
Pen Duration on Standard Protocol: Up to 40 doses per pen (full pen lasts ≈40 days with daily use)
Administration Instructions:
Wash hands and prepare a clean surface.
Attach a sterile needle.
Dial the required number of clicks.
Clean injection site (abdomen or upper thigh) with alcohol swab.
Insert needle at 45-90° angle and inject slowly.
Withdraw needle, dispose safely, and cap the pen.
Rotate injection sites to minimize irritation.
Always inspect solution before use: Do not inject if cloudy, discoloured, or containing particles.
Side Effects
Somatropin is generally well tolerated at physiological replacement doses. Common or potential adverse reactions include:
Arthralgia, myalgia, or carpal tunnel syndrome (usually transient)
Headache or light-headedness
Glucose intolerance or hyperglycaemia
Rare: Intracranial hypertension (pseudotumor cerebri), pancreatitis, hypothyroidism, gynecomastia (in males)
If any severe or persistent symptoms occur (e.g., severe headache with visual changes, severe abdominal pain, or signs of allergic reaction), discontinue use and contact your healthcare provider immediately.
Storage & Handling
Store either in refrigerator (fridge); never freeze or in a cool dry place (≤25-30°C / 77-86°F). Keep pen capped and protected from light and heat.
After first use: Same storage conditions.
Keep out of reach of children.
Discard if expired or solution appears abnormal.
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IMPORTANT NOTICE
This product is not intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA, SAHPRA, or other authorities. Always consult a licensed healthcare provider before use, especially if pregnant, breastfeeding, under 18, or managing medical conditions.
