MOTS-C 10mg – HD Laboratories
MOTS-C is a mitochondrial-derived peptide (MDP) researched for its role in cellular energy regulation and metabolic signaling. Naturally encoded within mitochondrial DNA, MOTS-C functions as a metabolic messenger that helps regulate stress adaptation, glucose utilization, and mitochondrial efficiency.
The 10mg vial by HD Laboratories contains high-purity lyophilized MOTS-C intended for laboratory and research applications.
Mechanism of Action
MOTS-C is classified as a mitochondrial “mitokine” and primarily exerts its effects through metabolic signaling pathways:
AMPK Activation – Stimulates AMP-activated protein kinase, a key cellular energy sensor.
Enhanced Glucose Uptake – May promote improved glucose utilization at the cellular level.
Fatty Acid Oxidation Support – Encourages metabolic flexibility.
Nuclear Gene Regulation – Influences transcription factors associated with stress adaptation and metabolic balance.
Mitochondrial Efficiency – Supports cellular resilience under metabolic stress conditions.
Its mechanism makes it a peptide of interest in research related to metabolic health, body composition, endurance performance, and longevity pathways.
Potential Research Applications
While human clinical data remains limited, MOTS-C is commonly explored in research contexts for:
Metabolic optimization
Insulin sensitivity support
Body composition improvement
Exercise endurance and recovery
Healthy aging and mitochondrial support
All applications remain investigational.
Recommended Research Dosing Protocols
⚠ There are no FDA-approved or clinically established human dosing guidelines for MOTS-C. The following reflects commonly observed research practices and community protocols.
General Administration
Route: Subcutaneous (SC) injection
Typical Dose Range: 5–10mg per administration
Frequency: 2–3 times per week
Cycle Duration: 4–12 weeks
Break Period: 4–8 weeks off between cycles
Storage: Refrigerate at 2–8°C after reconstitution
Goal-Specific Protocol Examples
1. Metabolic Optimization
Dose: 5–10mg
Frequency: 2–3× weekly
Timing: Morning or before meals
Cycle: 8–12 weeks
Intended to align with circadian metabolic signaling and glucose regulation pathways.
2. Body Composition & Fat Oxidation
Dose: ~10mg per week (split into 2–3 injections)
Timing: 30–60 minutes before exercise
Cycle: 8–12 weeks
Often paired with structured nutrition and resistance training protocols.
3. Endurance & Athletic Performance
Dose: 10mg weekly (divided doses)
Timing: 30–60 minutes pre-workout
Cycle: 6–8 weeks
Explored for its interaction with exercise-induced AMPK activation.
4. Longevity & Mitochondrial Research
Dose: 5–10mg weekly
Frequency: 2× weekly
Cycle: 10–12+ weeks
Focuses on mitochondrial stress resilience and metabolic health pathways.
Timing Considerations
Morning administration may align with fasting metabolic activity.
Pre-workout dosing is often utilized to synergize with exercise-induced metabolic activation.
Consistency in weekly timing appears more important than exact hour of administration.
Administration Guidelines
Reconstitute with bacteriostatic water using sterile technique.
Inject subcutaneously using an insulin syringe.
Rotate injection sites (abdomen, thigh, upper arm).
Do not shake vigorously during reconstitution.
Discard if solution becomes cloudy or discolored.