Description ARA-290 (Cibinetide) is a synthetic 11-amino-acid peptide derived from erythropoietin (EPO). It selectively activates the innate repair receptor (IRR) without stimulating red blood cell production.Chemical Structure Sequence: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (pyroglutamate at N-terminus).Mechanism of Action ARA-290 binds to the tissue-protective IRR complex (EPOR + βcR), triggering potent anti-inflammatory, anti-apoptotic, and regenerative signalling in nerves and other tissues. It promotes:
Axonal repair, remyelination, and nerve regeneration
Reduction of neuropathic pain and neuroinflammation
Improvement of microvascular function and tissue oxygenation
Activation of protective pathways (JAK2/STAT3, PI3K/Akt) while avoiding hematopoietic effects
Indications & Usage Nerve Repair (ARA-290 / Cibinetide) is used to support nerve regeneration and neuropathic recovery. It is indicated for:
Promotion of peripheral nerve repair and regeneration
Reduction of neuropathic pain and neuroinflammation
Support for recovery from nerve injury, compression, diabetic neuropathy, or post-surgical nerve damage
Assistance in tissue protection and functional recovery
Contraindications & Warnings Do not use if you have:
Known hypersensitivity to ARA-290 or any excipient
Active malignancy or history of cancer
Severe uncontrolled cardiovascular disease
Pregnancy or breastfeeding
Age under 18 years
Warnings
Use only under medical supervision with appropriate monitoring.
Not a substitute for standard medical or surgical treatment of neuropathy or nerve injury.
Monitor for changes in pain levels or neurological function.
Discontinue immediately and seek medical attention if severe symptoms occur (e.g., worsening neurological deficits or allergic reaction).
Dosage & Administration
Subcutaneous injection only.
Standard Dose: 2–4 mg (10–19 clicks) per injection (common research range scaled for 50 mg pen)
Frequency: Once daily or every other day
Timing: Consistent daily timing (evening preferred for nerve recovery)
Cycle: Typically 4–8 weeks on, followed by 2–4 weeks off
Administration Instructions:
Wash hands and prepare a clean surface.
Attach a sterile needle.
Dial your dose (e.g., 12 clicks ≈ 2.5 mg).
Clean injection site (abdomen or thigh) with alcohol swab.
Insert needle at 45–90° angle and inject slowly.
Withdraw needle, dispose safely, and cap the pen.
Rotate injection sites to minimize irritation.
Always inspect solution: Do not inject if cloudy, discoloured, or containing particles.
Side Effects ARA-290 is generally well tolerated. Reported reactions are uncommon and usually mild/transient, including:
Mild injection-site irritation, redness, or itching
Transient headache or light-headedness
Temporary changes in energy levels or mild fatigue
Rare mild gastrointestinal discomfort
If any severe or persistent symptoms occur (e.g., worsening pain, neurological changes, or allergic signs), discontinue use and contact your healthcare provider immediately.
Storage & Handling
Store either in refrigerator (fridge); never freeze or in a cool dry place (≤25–30°C / 77–86°F).
Keep pen capped and protected from light and heat.
After first use: Same storage conditions.
Keep out of reach of children.
Discard if expired or solution appears abnormal.
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IMPORTANT NOTICE
This product is not intended to diagnose, treat, cure, or prevent any disease. Statements have not been evaluated by the FDA, SAHPRA, or other authorities. Always consult a licensed healthcare provider before use, especially if pregnant, breastfeeding, under 18, or managing medical conditions.
